منابع مشابه
Antigen Specificity of Human TCR Cells
T cells expressing the TCR constitute a small fraction of T cells in circulating blood whereas they are abundant in some peripheral lymphoid organs and mucosal sites. The TCR V 9/V 2 heterodimer is expressed on a large fraction of human TCR cells. This receptor is activated by endogenous and bacterial phosphorylated metabolites, which accumulate in tumour transformed cells and in bacteria-infec...
متن کاملT-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions*
αβ T-cell receptors (TCRs) engage antigens using complementarity-determining region (CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged (CDR3). TCR ligands compose a presentation platform (major histocompatibility complex (MHC)) and a variable antigenic component consisting of a short "foreign" peptide. The sequence of events when the TCR engages its peptide-...
متن کاملPredicting Specificity in Classroom Discussion
High quality classroom discussion is important to student development, enhancing abilities to express claims, reason about other students’ claims, and retain information for longer periods of time. Previous small-scale studies have shown that one indicator of classroom discussion quality is specificity. In this paper we tackle the problem of predicting specificity for classroom discussions. We ...
متن کاملFunctional evidence for TCR-intrinsic specificity for MHCII.
How T cells become restricted to binding antigenic peptides within class I or class II major histocompatibility complex molecules (pMHCI or pMHCII, respectively) via clonotypic T-cell receptors (TCRs) remains debated. During development, if TCR-pMHC interactions exceed an affinity threshold, a signal is generated that positively selects the thymocyte to become a mature CD4(+) or CD8(+) T cell t...
متن کاملNRPSpredictor2—a web server for predicting NRPS adenylation domain specificity
The products of many bacterial non-ribosomal peptide synthetases (NRPS) are highly important secondary metabolites, including vancomycin and other antibiotics. The ability to predict substrate specificity of newly detected NRPS Adenylation (A-) domains by genome sequencing efforts is of great importance to identify and annotate new gene clusters that produce secondary metabolites. Prediction of...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2017
ISSN: 1600-6135,1600-6143
DOI: 10.1111/ajt.14470